2025
[1]Chuqi Liu#, Dexiang Liu#, Xiang Zheng#, Jiali Guan, Xinyan Zhou, Haikun Zhang, Shen Wang, Qiubai Li, Gan Lu, Jun He* & Cong Ma*. Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.nature communications.13 October 2025.9080 (2025) .doi.org/10.1038/s41467-025-64149-9(通讯作者)
[2]Kexu Zhao, Li Zhang, Mengshi Lei, Ziqi Jin, Tianxin Du, Hong Zhang, Yin Sheng, Zhitao Hu, shenwang，Cong Ma* A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis. Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2508915122. doi: 10.1073/pnas.2508915122.(通讯作者)
[3] Haowen Liu, Lei Li, Jiafan Wang, Jiayi Hu, Jingyao Xia, Xiaochun Yu, Jing Tang, Huisheng Liu, Xiaofei Yang, Cong Ma, Lijun Kang, Zhitao Hu*. Mechanisms that regulate the C1-C2B mutual inhibition control functionalswitch of UNC-13. Elife. 2025 Apr 11;14:RP105199. doi: 10.7554/eLife.105199.
[4] Ya Wang, Chun Hin Chow, Yu Zhang, Mengjia Huang, Randa Higazy, Neeraja Ramakrishnan, Lili Chen, Xuhui Chen, Yixiang Deng, Sheng Wang, Cuntai Zhang, Cong Ma*, Shuzo Sugita*, Shangbang Gao*. The exocytosis regulatorcomplexin controls spontaneous synaptic vesicle release in a CAPS-dependentmanner at C. elegans excitatory synapses. PLoS Biol. 2025 Feb 6;23(2):e3003023. doi: 10.1371/journal.pbio.3003023.(通讯作者).
[5]Fenglei Jian, Shen Wang, Wenmin Tian, Yang Chen, Shixuan Wang, Yan Li, Cong Ma, Yueguang Rong*. DeacetylatedSNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent ofSTX17. Nat Commun. 2025 Jan 9;16(1):543. doi: 10.1038/s41467-025-55906-x.
2024
[1] Hong Zhang#, Mengshi Lei#, Yu Zhang, Hao Li, Zhen He, Sheng Xie, Le Zhu, Shen Wang, Jianfeng Liu, Yan Li, Youming Lu*, Cong Ma*. Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release. Science Advances. 2024. 10(20):eadi7024. doi:10.1126/sciadv.adi7024.（通讯作者）.
[2] Shen Wang, Cong Ma*. A practical guide for fast implementation of SNARE-mediated liposome fusion. Biophysics Reports. 2024. 10(1):31. doi: 10.52601/bpr.2023.230017.（通讯作者）.
[3] Fenglei Jian#, Shen Wang#, Rui Tian, Yufen Wang, Chuangpeng Li, Yan Li, Shixuan Wang, Chao Fang, Cong Ma*, Yueguang Rong*. The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion. Cell Research. 2024. 34:151-168. doi: 10.1038/s41422-023-00916-x.（通讯作者）.
[4] Mengshi Lei, Weiyou Wang, Hong Zhang, Jihong Gong, Hanmian Cai, Zhili Wang, Le Zhu, Xiaofei Yang, Shen Wang, Cong Ma*. Piezo1 Regulates Stiffness-Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics. Adv Sci (Weinh). 2024 Dec;11(47):e2405705. doi: 10.1002/advs.202405705. (通讯作者)
[5] Chuchu Wan, Si He, Quanyong Cheng, Kehan Du, Yuhang Song, Xiang Yu, Hao Jiang, Caili Huang*, Jiangping Xu, Cong Ma, Jintao Zhu. Bridged emulsion gels from polymer-nanoparticle enabling large-amount biomedical encapsulation and functionalization. Nat Commun. 2024 Dec 30;15(1):10789. doi: 10.1038/s41467-024-55099-9.
[6] Ping-Fen Yang, Tai-Lei Nie, Xia-Nan Sun, Lan-Xin Xu, Cong Ma, Fang Wang, Li-Hong Long, Jian-Guo Chen. Wheel-Running Exercise Alleviates Anxiety-Like Behavior via Down-Regulating S-Nitrosylation of Gephyrin in the Basolateral Amygdala of Male Rats. Adv Sci (Weinh). 2024 Sep;11(34):e2400205. doi: 10.1002/advs.202400205. Epub 2024 Jul 4. Erratum in: Adv Sci (Weinh). 2025 Feb;12(7):e2415925. doi: 10.1002/advs.202415925.
2023
[1] Mengshi Lei, Weiyou Wang, Hong Zhang, Jihong Gong, Zhili Wang, Hanmian Cai, Xiaofei Yang, Shen Wang, Cong Ma*. Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation. Cell Reports. 2023. 42(12):113522. doi: 10.1016/j.celrep.2023.113522.（通讯作者）.
[2] Qingfang Shao#, Chandra Sugiarto Wijaya#, Shen Wang#, Xinan Meng, Cheng Yuan, Cong Ma*, Suhong Xu*. The SNARE complex formed by RIC-4/SEC-22/SYX-2 promotes C. elegans epidermal wound healing. Cell Reports. 2023. 42(11):113349. doi: 10.1016/j.celrep.2023.113349.（通讯作者）.
[3] Chuqi Liu#, Dexiang Liu#, Shen Wang, Lu Gan, Xiangliang Yang, Cong Ma*. Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion. Journal of Extracell Vesicles. 2023. 12(9):12356. doi: 10.1002/jev2.12356.（通讯作者）.
[4] Li Zhang#, Lei Li#, Ziqing Wei, Hao Zhou, Haowen Liu, Shen Wang, Yijing Ren, Tiankai Dai, Jiafan Wang, Zhitao Hu*, Cong Ma*. The C2 and PH domains of CAPS constitute an effective PI (4, 5) P2-binding unit essential for Ca2+-regulated exocytosis. Structure. 2023. 31(4):424-434. doi: 10.1016/j.str.2023.02.004.（通讯作者）.
[5] Yan Zhang#, Yaru Hu#, Huayong Xie, Maili Liu, Jun Yang*, Cong Ma*. Structural Mechanism of Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Assembly in Lipid Bilayers Revealed by Solid-State NMR. Journal of the American Chemical Society. 2023. 145(19):10641-10650. doi: 10.1021/jacs.3c00764.（通讯作者）.
[6] Rui Zhang, Yuyan Yang, Chao He, Xin Zhang, Vincenzo Torraca, Shen Wang, Nan Liu, Jiaren Yang, Shicheng Liu, Jinglei Yuan, Dongzhi Gou, Shi Li, Xueying Dong, Yufei Xie, Junling He, Hua Bai, Mengyu Hu, Zhiquan Liao, Yuan Huang, Hao Lyu, Shuai Xiao, Dong Guo, Declan William Ali, Marek Michalak, Cong Ma, Xing-Zhen Chen, Jingfeng Tang*, Cefan Zhou*. RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex. Cell Death Differ. 2023 Oct;30(10):2231-2248. doi: 10.1038/s41418-023-01215-z.
[7] Xianping Wang, Jihong Gong, Le Zhu, Huidan Chen, Ziqi Jin, Xiaoqiang Mo, Shen Wang*, Xiaofei Yang*, Cong Ma. Identification of residues critical for the extension of Munc18-1 domain 3a. BMC Biol. 2023 Jul 13;21(1):158. doi: 10.1186/s12915-023-01655-6.
2022
[1] Shen Wang, Cong Ma*. Neuronal SNARE complex assembly guided by Munc18-1 and Munc13-1. FEBS Open Bio. 2022. 12(11):1939-1957. doi: 10.1002/2211-5463.13394.（通讯作者）.
[2] Yuanyuan Xu#, Le Zhu#, Shen Wang*, Cong Ma*. Munc18 - Munc13-dependent pathway of SNARE complex assembly is resistant to NSF and α-SNAP. FEBS Journal. 2022. 289(20):6367-6384. doi: 10.1111/febs.16528.（通讯作者）.
[3] Tianzhi Li, Qiqi Cheng, Shen Wang, Cong Ma*. Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis. Elife. 2022. 11:e79926. doi: 10.7554/eLife.79926.（通讯作者）.
[4] Shen Wang, Cong Ma*. Stability profile of the neuronal SNARE complex reflects its potency to drive fast membrane fusion. Biophysical Journal. 2022. 121(16):3081-3102. doi: 10.1016/j.bpj.2022.07.013.（通讯作者）.
[5] Wen-Long Xie, Hui-Ling Zheng, Hou-Hong Li, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Cong Ma, Jian-Feng Liu, Zhuang-Li Hu, Lan Ni, You Jin, Fang Wang*, Jian-Guo Chen*. Deficiency of Glycosylated α-Dystroglycan in Ventral Hippocampus Bridges the Destabilization of Gamma-Aminobutyric Acid Type A Receptors With the Depressive-like Behaviors of Male Mice. Biol Psychiatry. 2022 Mar 15;91(6):593-603. doi: 10.1016/j.biopsych.2021.10.022.
[6] Jihong Gong, Xiaofei Yang, Cong Ma*. Monitoring Synaptic Exocytosis Using a Whole-Cell Patch Clamp Technique. Methods Mol Biol. 2022;2473:89-100. doi: 10.1007/978-1-0716-2209-4_8. (通讯作者)
2021
[1] Jihong Gong, Xianping Wang, Chaoyang Cui, Yuyang Qin, Ziqi Jin, Cong Ma*, Xiaofei Yang*. Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex. Front Mol Neurosci. 2021 Dec 22;14:785696. doi: 10.3389/fnmol.2021.785696.（通讯作者）
[2] Di Peng, Chen Ruan, Shanshan Fu, Chengwen He, Jingzhen Song, Hui Li, Yiran Tu, Dachao Tang, Lan Yao, Shaofeng Lin, Ying Shi, Weizhi Zhang, Hao Zhou, Le Zhu,
Cong Ma, Cheng Chang, Jie Ma, Zhiping Xie, Chenwei Wang*, Yu Xue*. Atg9-centeredmulti-omics integration reveals new autophagy regulators in
Saccharomyces cerevisiae. Autophagy. 2021 Dec;17(12):4453-4476. doi: 10.1080/15548627.2021.1898749.
[3] Yanrui Yang, Jiang Chen, Xue Chen, Di Li, Jianfeng He, Shen Wang, Shun Zhao, Xiaoyu Yang, Shikun Deng, Chunfang Tong, Dou Wang, Zhenzhen Guo, Dong Li,
Cong Ma, Xin Liang, Yun S. Shi, Jia-Jia Liu*.Endophilin A1 drives acutestructural plasticity of dendritic spines in response to Ca2+/calmodulin. J CellBiol.
2021 Jun 7;220(6):e202007172. doi: 10.1083/jcb.202007172.
[4] Yaru Hu, Le Zhu and Cong Ma*. Structural Roles for the Juxtamembrane Linker Region andTransmembrane Region of Synaptobrevin 2 in Membrane Fusion. Front
Cell Dev Biol.2021 Jan 6;8:609708. doi: 10.3389/fcell.2020.609708.(通讯作者).
2020
[1] Xianping Wang#, Jihong Gong#, Le Zhu#, Shen Wang, Xiaoyu Yang, Yuanyuan Xu, Xiaofei Yang, Cong Ma*. Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly. The EMBO Journal. 2020. 39(16):e103631. doi: 10.15252/embj.2019103631.（通讯作者）.
[2] Shen Wang, Yun Li, Cong Ma*. Atg3 promotes Atg8 lipidation via altering lipid diffusion and rearrangement. Protein Science. 2020. 29(6):1511-1523. doi: 10.1002/pro.3866.（通讯作者）.
[3] Yulei Li, Lei Jiang, Lejin Wang, Cheng Wang, Chunjie Liu, Anyuan Guo, Mugen Liu, Luoying Zhang, Cong Ma, Xianqin Zhang*, Shangbang Gao,
Jing Yu Liu* p.His16Arg of STXBP1 (MUNC18-1) Associated With Syntaxin 3BCauses Autosomal Dominant Congenital Nystagmus. Front Cell Dev Biol.
2020 Nov4;8:591781. doi: 10.3389/fcell.2020.591781.
2019
[1] Nils Brose, Axel T Brunger, David Cafiso, Edwin R Chapman, Jiajie Diao, Frederick M Hughson, Meyer B Jackson, Reinhard Jahn, Manfred Lindau, Cong Ma, Josep Rizo, Yeon-Kyun Shin, Thomas H S?llner, Lukas Tamm, Tae-Young Yoon, Yongli Zhang. Synaptic vesicle fusion: today and beyond. Nature Structural & Molecular Biology. 2019. 26(8):663-668. doi: 10.1038/s41594-019-0277-z.
[2] Hao Zhou#, Ziqing Wei#, Shen Wang, Deqiang Yao, Rongguang Zhang, Cong Ma*. Structural and functional analysis of the CAPS SNARE-binding domain required for SNARE complex formation and exocytosis. Cell Reports. 2019. 26(12):3347-3359. doi: 10.1016/j.celrep.2019.02.064.（通讯作者）.
[3] Shen Wang#, Yun Li#, Jihong Gong, Sheng Ye, Xiaofei Yang, Rongguang Zhang, Cong Ma*. Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly. Nature Communications. 2019. 10(1):69. doi: 10.1038/s41467-018-08028-6.（通讯作者）.
[4] Wenjie Huang, Zhe Liu, Fan Yang, Huan Zhou, Xin Yong, Xiaoyu Yang, Yifei Zhou, Lijia Xue, Yihong Zhang, Dingdong Liu, Wentong Meng, Wenming Zhang, Xiaohu Zhang, Xiaofei Shen, Qingxiang Sun, Li Li, Cong Ma, Yuquan Wei, Daniel D. Billadeau, Xianming Mo, and Da Jia*. Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22598-22608. doi: 10.1073/pnas.1909316116.
2018
[1] Yun Li#, Shen Wang#, Tianzhi Li, Le Zhu, Cong Ma*. Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13. FEBS Letters. 2018. 592(7):1161-1172. doi: 10.1002/1873-3468.13018.（通讯作者）.
[2] Hongying Ma, Shenglei Feng, Xuejun Deng, Li Wang, Sheng Zeng, Cheng Wang, Xixiang Ma, Hao Sun, Rui Chen, Shiyue Du, Jinglin Mao, Xianwei Zhang, Cong Ma, Hong Jiang, Luoying Zhang, Beisha Tang*, Jing Yu Liu*. A PRRT2 variant in a Chinese family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures results in loss of interaction with STX1B. Epilepsia. 2018 Aug;59(8):1621-1630. doi: 10.1111/epi.14511.
[3] Jialin Yao, Fan Yang, Xiaodong Sun, Shen Wang, Ninghai Gan, Qi Liu, Dingdong Liu, Xia Zhang, Dawen Niu, Yuquan Wei, Cong Ma, Zhao-Qing Luo, Qingxiang Sun*, Da Jia*. Mechanism of inhibition of retromer transport by the bacterial effector RidL. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1446-E1454. doi: 10.1073/pnas.1717383115.
2017
[1] Yun Li#, Shen Wang#, Tianzhi Li, Le Zhu, Yuanyuan Xu, Cong Ma*. A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13. Frontiers in Molecular Neuroscience. 2017. 10:256. doi: 10.3389/fnmol.2017.00256.（通讯作者）.
[2] Shen Wang, Ucheor B Choi, Jihong Gong, Xiaoyu Yang, Yun Li, Austin L Wang, Xiaofei Yang*, Axel T Brunger*, Cong Ma*. Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis. EMBO J. 2017 Mar 15;36(6):816-829. doi: 10.15252/embj.201695775.(通讯作者).
[3] Xiaoxia Liu, Alpay Burak Seven, Junjie Xu, Victoria Esser, Lijing Su, Cong Ma, Josep Rizo*. Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion. Nat Protoc. 2017 Sep;12(9):2014-2028. doi: 10.1038/nprot.2017.068.
[4] Junjie Xu, Marcial Camacho, Yibin Xu, Victoria Esser, Xiaoxia Liu, Thorsten Trimbuch, Yun-Zu Pan, Cong Ma, Diana R Tomchick*, Christian Rosenmund*, Josep Rizo*. Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN. Elife. 2017 Feb 8;6:e22567. doi:10.7554/eLife.22567.
2016
[1] Shen Wang#, Yun Li#, Cong Ma*. Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion. ELife. 2016. 5:e14211. doi: 10.7554/eLife.14211.（通讯作者）.
[2] Xiaoxia Liu, Alpay Burak Seven, Marcial Camacho, Victoria Esser, Junjie Xu, Thorsten Trimbuch, Bradley Quade, Lijing Su, Cong Ma,
Christian Rosenmund, Josep Rizo*.Functional synergy between the Munc13 C-terminal C1 and C2 domains. Elife. 2016 May 23;5:e13696. doi: 10.7554/eLife.13696.
2015
[2] Xiaoyu Yang#, Shen Wang#, Yi Sheng#, Mingshu Zhang, Wenjuan Zou, Lijie Wu, Lijun Kang, Josep Rizo, Rongguang Zhang, Tao Xu*, Cong Ma* . Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming. Nature Structural & Molecular Biology. 2015. 22(7):547-554. doi: 10.1038/nsmb.3038.（通讯作者）.
2013
[1] Cong Ma#*, Lijing Su#, Alpay B Seven, Yibin Xu, Josep Rizo*. Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release. Science. 2013. 339(6118):421-425. doi: 10.1126/science.1230473. （共同第一作者,通讯作者）.